Electrophysiological effects of isoproterenol on Purkinje fibers of the heart.
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چکیده
منابع مشابه
Acetylcholine antagonism of the electrophysiological effects of isoproterenol on canine cardiac Purkinje fibers.
The purpose of these experiments was to determine whether or not acetylcholine modulated the electrophysiological effects of isoproterenol on canine cardiac Purkinje fibers. Conventional microelectrode techniques were used. Predictably, isoproterenol produced shortening of action potential duration; acetylcholine significantly blunted this effect of isoproterenol. Isoproterenol restored excitab...
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We studied the role of the anticholinergic properties of disopyramide and quinidine in mediating the electrophysiological effects of these agents on isolated cardiac tissue. In right atria, disopyramide, quinidine, and procainamide administered alone elicited negative chronotropic responses. However, after cholinergic stimulation with physostigmine (1 X 10" M), disopyramide and quinidine produc...
متن کاملElectrophysiological Effects of Disopyramide and Quinidine on Guinea Pig Atria and Canine Cardiac Purkinje Fibers
We studied the role of the anticholinergic properties of disopyramide and quinidine in mediating the electrophysiological effects of these agents on isolated cardiac tissue. In right atria, disopyramide, quinidine, and procainamide administered alone elicited negative chronotropic responses. However, after cholinergic stimulation with physostigmine (1 X 10" M), disopyramide and quinidine produc...
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We determined age-related differences in automaticity and responsiveness of cardiac Purkinje fibers from adult and neonatal dogs to graded concentrations of epinephrine, isoproterenol, and phenylephrine. Purkinje fibers were studied with standard microelectrode techniques during superfusion with Tyrode's solution at 37 degrees C. Control spontaneous rates for adults and neonates did not differ ...
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In man, therapeutic doses of imipramine suppress ventricular arrhythmias, and toxic doses can cause severe intraventricular conduction disturbances and cardiac arrest. To determine the cellular mechanisms responsible for these actions, we studied the effects of imipramine hydrochloride at concentrations from 3 x 1<T to 3 x 10~ g/ml on the transmembrane potentials of sheep and calf Purkinje and ...
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عنوان ژورنال:
- Circulation research
دوره 19 5 شماره
صفحات -
تاریخ انتشار 1966